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Wales have already been qualified for the World Cup quarter-finals but theyll aim to win their pool all games for the very first time since 1987 when they face Uruguay.
The side of warren Gatland need two points to finish top of Pool D, thanks to their head-to-head record against Australia.
And though Uruguay stunned Fiji earlier in the championship, Wales will anticipate to succeed comprehensively.
Gatland has made 13 changes with four days to recover from Wednesdays bruising win over Fiji.
Wing Josh Adams and middle Hadleigh Parkes keep their places as Gatland said, even they would have been rested had Wales not continued numerous harms against the imposing Fijians.
Fly-half Dan Biggar and center Jonathan Davies were driven off the field with head and knee injuries , while Adams suffered a leg and fellow wing George North hurt his ankle.
So with more needing a break and a small number of players injured, Sunday Gatland is aiming to safeguard as much as he can from harm in front of a probable quarter-final against France a week.
That means first World Cup looks for wing Hallam Amos and Bradley Davies, hooker Ryan Elias, scrum-half Aled Davies and rows Adam Beard.
Lots of the players who started at the wins over Australia, Georgia and Fiji will hope to recover their positions – however Gatland has cautioned that is no foregone conclusion.
it is a tiny juggling act with the four-day turnaround, he said.
We knew from the beginning that we were going to expose a few players. About entering this game with just one 10 15, we talked before the World Cup.
So we have been looking at cover there. Its been hard with the turnaround.
We have a new forward bunch and theyre eager and looking forward to an opportunity.
The message to the gamers from Uruguay is the door isnt shut.
There are chances for players to go out there and rejuvenate and stake a claim to get a quarter-final spot.
Uruguay will be bidding to win two matches in a World Cup campaign for the first time.
They have won one pool game on two occasions in 2003 and 1999 – however, the victory over Fiji has given them the opportunity to create history.
Los Teros have lost all eight of the World Cup fixtures against Tier 1 sides.
And even though Wales hammered them 54-9 their win against Fiji was evidence of their own improvement.
Captain Juan Manuel Gaminara talked passionately about the progress of his team after that momentous victory, and he needs Uruguay to be granted more chances to test themselves from teams such as Wales.
We dont believe we ought to have to wait for every four years to perform Tier One groups, he said.
We ought to play with them every year
Wales: Halfpenny; Adams, Watkin, Parkes, Amos; Patchell, A Davies; Smith, Elias, Lewis, B Davies, Beard, Shingler, Tipuric (capt), Wainwright.
Replacements: Dee, Carre, W Jones, Ball, Moriarty, James Davies, T Williams, G Davies.
Uruguay: Mieres; Leivas, Cat, Vilaseca, Freitas; Berchesi, Arata; Sanguinetti, Kessler, Arbelo, Dotti, Leindeker, Gaminara (capt), Civetta, Nieto.
Replacements: Pujadas, Echeverria, Rombys, Magno, Diana, Ormaechea, Inciarte, Silva.
Officials: Referee, Angus Gardner (Australia); Assistant referees, Luke Pearce (England), Karl Dickson (England); TMO, Rowan Kitt (England).
Wales head coach Warren Gatland:We have got to make sure we do a work early on against Uruguay. It is hard with such a brief turnaround but that is what World Trainers are about.
Weve talked about producing as much power in depth in the team as we can within the previous three or four years.
The squad is in a great place emotionally. You will find a group of gamers who are excited about the chance get their very first game to head out as well as for a great deal of them.
We are expecting another tough game but also a great performance from both sides .
Uruguay captain Juan Manuel Gaminara:weve been visualising winning two games in the World Cup since, if we do, we qualify for France 2023 mechanically.
We are getting better as the tournament continues. We only play three to four times annually. We are getting accustomed to this many games in a short time period.
We must disrupt Waless kicking game. We notice their number 9 usually kicks a whole lot so we have to worry that kick
This is going to be the second of two World Cup matches to be played a stadium, in Kumamoto Stadium.
France beat Tonga 23-21 final Sunday in another match in the ground, which is similar in layout to the Thomond Park and Hong Kong Stadium of Munster.