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Scotland head coach Gregor Townsend has produced 14 adjustments for Wednesdays World Cup assembly with Russia.
Winger Darcy Graham is the only player retained final week from the starting XV that defeated Samoa 34-0.
Experienced flanker John Barclay contributes to direct the side with been dropped following the opening loss to Ireland.
Essential players have been rested on Sunday for a possible assembly Pool A leaders Japan.
Scotland want a bonus-point triumph over Russia to go into the final group game four factors behind the host nation.
Center Pete Horne, full-back Blair Kinghorn, lock although the Horne brother, George, begins after coming off the bench against Samoa, hooker George Turner along with Ben Toolis will make their first appearances in Japan.
He joins together with all star fly-half Finn Russell among those, with Glasgow Warriors team-mate Adam Hastings.
Fraser Brown, also a substitute hooker from the two games, is chosen in the back row, along with Barclay and Ryan Wilson.
First and foremost weve picked a team we believe is capable of defeating an increasingly remarkable and combative Russia side, who want to complete their Pool effort on a top, said Townsend.
Any successful World Cup campaign is constructed on a team effort and also those gamers who didnt get the chance to start against Samoa actually helped supply that team with an excellent week of preparation.
Now its their chance to get trapped to our next major game.
Russia, ranked 20th in the world, are without a stage in Japan after three beats.
Scotland: Kinghorn; Seymour, Taylor, P Horne, Graham; G Horne, Hastings; Reid, Turner Cummings Barclay Wilson.
Replacements: McInally Nel, Gilchrist, Bradbury Pyrgos, Harris.
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